Conclusions The balance between MMPs and their natural inhibitors is disturbed in patients with Dupuytren�"s disease. The decrease in MMP-to-TIMP expression can cause increased synthesis and deposition of collagen, leading to palmar fibromatosis. The high expression of MMP2 may represent an unsuccessful attempt to reduce collagen deposition. In the future, a treatment that downregulates TIMPs but increases the activity of MMPs may be an appropriate therapy for Dupuytren�"s disease. Content Type Journal ArticleCategory Orthopaedic SurgeryDOI 10.1007/s00402-008-0726-3AuthorsDietmar Ulrich, Aachen University of Technology Department of Plastic Surgery, Hand Surgery, Burn Unit, University Hospital, Medical Faculty of the University of Technology Pauwelsstrasse 30 5207...
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